#iCalcineirin Consensus 90% slLHlss__hu__............................................______l___l__b___......_____-LlllsGsl........s__u___ph__h__hL__l___l_l__p......RhhhVPG_pDls.................___s_shh_p_pu_p__s__sa__php_a__hh__h_____.__h___.p_Wshh_.......................hs_l__hlAGhNooh......__sc..____s_hs__Q___hs_._l______s_hRluhh_Hs___..........................__h_s__________......_lphlh_s_... Consensus 80% olLHlss_phu__....................................__s.....__l___l__-l__l___......_s__PDLllloGDL........s__u___EhppA__FL__L___L_l__p......RlhlVPGs+Dls.................b_hhpuYh_ppcup-__P__PaasKap_as_hhppha_s_____F___.pPWola_.......................hPpLpshlAGLNSTh......s_oHb_psp_ublG__Qh__hsp._Lp_h___sWLRlGhhpHss_____.................._....__lcD___h___hs_......_lplllpG___. Consensus 70% olLHlus_+FG_s..............................__...._ss.....p_L__pl_sDlp_L_s_......_u__PDLlVVoGDL........opsG__pEappA_sFLssL___LsL__p......RlhlVPGsHDVs.................p_hhcuYF_ph-Ac-_pP_sPYWsKWcpas_hFpchY_s_s_s_Fpss.pPWoLF_.......................hP-LclVVAGLNSTh......A_oHb_pscaGhlGp_Qh_aFAc.pLp_acppGWLRlGhl+Hss_____.................._....__L+Ds__h__hlus......pLpLLl+G_s_. Consensus 60% TlLHlussRFG_s____..........................s_...__ss.....psLbsclhuDls_Lscp......_uspPDLlVVoGDL........TcsGp_pEFcpAhsFLsuL_s_LsLs_c......RlllVPGsHDVN.................c_ACcAYFhpCEA--bcP_sPYWPKWc+FuphFpchYpslssh_Fsss.pPWoLFp.......................lP-L+VVVAGLNSTh......ApSHps-ccaGhlGc_Qh_WFAc.cLc_acpcGWLRlGll+HsPssss_...............__.s....s_LRDss_hsplLus......+LsLLLHG_s_. Consensus 50% TVLHLuGPRFG+s___s..........................ss...s_ss.....ssLpsclhuDLspLh-s......suspPDLlVVoGDL........TEoGsssEF-pAhsFLsuLsc_LuLs_c......RllVVPGsHDVN.................+sACcAYFhsCEAD-pcPpPPYWPKW+HFuphFscaYpulcsh_Fss-.QPWTLFc.......................lP-L+VVVAGLNSTM......AcSHRsED+aGhlG-sQAsWFA-.+L+sYcccGWLRIGlVHHsPsssss...............sc.s....ssLRDssslsclLGs......RLNLLLHGpss. separator ================================================================================================================================================================================================================================================================================================================================================================================== Domain Architecture ss_from:WP_080633877.1_A ---EE----E-CC-----------------------------------------------HHHHHHHHHHHHHH------CC--EEEEEE-C----------ECC--HHHHHHHHHHHHHHHHHHHHHCCC-EE--EEEE---CCCC-CCC--H---------HHHHHHHC--HHHH-CCCHHH--------HHHCCCCH--------------HHHHHHHCCC---C-CCEEEEEEE------ECCEEEEEEEE-CCC--------------C--CC--CC-E---CCC------CCEEEEEEECC-CCCE-C------------------C----CCC-HHHHHHHHHHH------H-CEEEE-CC-- WP_080633877.1 GILHLTDIHFSPE--------------------------------------------TDVSNKINGIANILTSN-----LQTCKIIFLIISGDI--------ANKGTAQEYEVAKTFIEKLSMAIKHAKKNVEI--RYIFVPGNHDCNLEKDSQ---------VRRNLIRDINYRSLGTDNTVI--------DFSLIVQE--------------DFWNFYSGYRAIPENKLYFKIQEK------IESYTICFHCLNTAW--------------MSKLKEEPGTLFFPVDKFNVENSANSLDIGVYHHPVNWFNP------------------T----TEKNNKREIQAFLDS------VSGIQFSGHEH- Calcineurin+nSTAND4+nSTAND4-C1 NUN13817.1 RWLHFADLQVGRS------------------------------DA---PIVA-----EDVRSELERDLRALHSQ------CGPW-DVVFLTGSLAADRRNPTSKGGSLPSVERNLGFLDSVLDSLWSYLQSLGSTPAVLALPGFGDME--------------------------SSIGAESDPAQ----RWEPFGHWIQSWYSRHPL-------PPWITLQ----------WGKVRADWRAVVFRDSARFGIAGLGSFVDKPEPPVVSDLPSLLQTIVGRPLPAWAGENDVNLLALSRPFR---AKHAPKNAFS-----------------------SALQ-----------------GISAILCGQ--- Calcineurin+BetaPropeller+sGTP_APGTPase+Calcineurin NUN13817.1 RILHLSDLHIFAD------------------------------------ADP-----KTLLQPLAADLRDKIDG-----MGIESLDLLVLSGDI--------TNYGTAAEFQQALLFVQELVKEFGLSSQ------RCMIVPGNHDLSWEHEVYDWKSARKVAIDKLTAGTFVRQGDGVLVRKELEYPGRFTHFSEHFYH-------PLFQ---QPYPLAP------EDQ---GISAW------FPQFKLQFLLLNTSVEI----DEYHQSRSMVSPKALAKALSAADGQIKQADRSDLLRIAVFHHPITG---------------------N----EKMEDDGFAEQLRKN------DVRLALHGHVH- Calcineurin+BetaPropeller+sGTP_APGTPase+Calcineurin NLT54662.1 TVLHLTDLRFGRDPSAAGGHRDGVGGHPGGVDGCPGVPRGHPGAE---PETP-----ESLFRRIDDDLAWLVAA------HGLRPDLVVVTGDL--------AEHGIRSELTRARDFLETLAEELRLPHD------RVVVVPGEHDVN-----------------YKACRAYFDLREADERRPVPPYWPKWGHFSESFERFYADVEGAMFPPD-EPWTLFE-----------------------LPELAVVVAGLNSTM------AESHLESDHHGWLGEQQLDWFAG-KLREYRDRGWLRLGAVHHRVTSAPVGAGA-----------AEEPESGRERLRDAARLDEALGR----PGLLNLLVHGHPR- Trypsin+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller+BetaPropeller WP_047222606.1 TVLHLAAPRIPRR--GA--------------------------DG---VRSA-----GELQARLWGDVTRLIHA------GASHPDLLVVTGDL--------TSSGHPREFEEALTFLAGLRALLSLEAH------RLVVVPGSHDIN-----------------QAAARAYFANCDADDIEPQPPYWPKWRHFANLFREVYQGIEGPLFDSA-QPWSLFH-----------------------VPDLDVAVAGLNSTM------AESHRDSDRYGYVGTAQAAWFAH-QLRPFEQAGVLRIGAVFHPPAPPGG--GPGER------AVDE-S----AVLRDTTAFDRLLGG------RLNLLLPGLQSP TIR+Calcineurin+iREase+NACHT+BetaPropeller WP_155373679.1 TLLHLADLRFGDDAVGG--------------------------DA---MREA-----DPYGQDLDLDLTRLIDE------QKLRPDLVVVTGDL--------TERGMPAEFARADRFLRGLTATLGLSRD------RLIVVPGDHDVN-----------------RIACEGYFKSQQADGVEPLAPFWPKWRHFAAMFRRLYDGVDSAEFTPD-RPWTLFE-----------------------VPGLSVVVAGLNSTM------ADSHQPEDHYGFCGDEQLAWFAE-RLRRYRSRGWLRIGAVHHDPLQVAG---------------RE-E----EHLRDVDRLVRILAP------ELNLLLHGNAH- Trypsin+Calcineurin+iREase+NACHT+BetaPropeller WP_181582471.1 SILHVAGPRFGHGLLRA--------------------------DS---PGEA-----DALREHILSGVAARVGR------GVPTPDLIVVSGDI--------TDSGSPTEFASAAAFLIGLRVRLNVWPD------RLLIVPGNHDVS-----------------KKACAAYFMRCEADEIPPQWPYAEKLDRYRRLFDELYRGLDQPRFDHD-RLWSLFP-----------------------IPELRVVVAGLNSTM------AATHLPDTDYGLIGDGQALWFEN-QLRGYEEREWLRLGLIRHDPLTKPG----------------D-P----TALHDGQALTAGLGD------RLHLLIHGPG-- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller MBA4159125.1 TVLHVSDPQFGKNHRFGRL------------------------AP---DMTP-DESFDTLLSRLKSDLDLLREE-----RHGLRPDLFIITGDL--------AEWGLKSEFEQALPFLVEITDHLELSRE------RVAIIPGNHDIN-----------------RRACESYFNDCEANEEEPRTPYWPKWRHYHWFFSQFFRDVPGFDFTED-EPWTIFE-----------------------VPDLKVVIAGLNSTM------RESHRDEDHYGWVGEAQLRWFAE-RLKRYREEGWFRIGAVHHNVRRGEV---------------AD-D----ENLRDADDLNQFVGP------YLNCLLHGHTH- Calcineurin+iREase+NACHT+BetaPropeller WP_192768493.1 TVLHVSDPQFGRHHLFG--------------------------GN---GQTPADQTYDTLHTRLHQDLTGLAEQ------HGLLPDLLLVTGDL--------AEWGLGSEFVQVTEFLAALSEAAELPRD------RVVIVPGNHDVN-----------------RKSCEGYFISEEGEERVPVPPYFPKWKQFTAAFEDFYADVPGVSFTPD-EPWTLFE-----------------------VPGLAVVVAGLNSTM------AESHRDADHYGWVGETQLRWFAD-RLADYRSRGWLRLAAVHHNVVRGAV---------------DD-E----ENLRDADDLDRILGE----PGLVNLLLHGHTH- Trypsin+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_178064717.1 TLLHLPGPRFARQPCAGP-------------------------AP---RQRA-----KELLDAVGSGVDRLLAT------GGTGPDALLISGDL--------TAAGGIREFDEALAFLARLRDVLDLDAG------RIAVVPGPHDVN-----------------HAACRAYFASCEADEVRPQPPYWDKWRHYFRFFTELYDGVDGPTFDRH-RPWSVFE-----------------------MPELNLVVAGINSTM------AESHLPDGHHGLVGAAQAHWFAR-RLDRYRSGGWLTAGLIGHPAAS--------------------------DAVRDHDSVAALLTP------RLHLLV------ TIR+Calcineurin WP_163553262.1 SVLHLSDLRFGGASEHH--------------------------GG-----------TAPPLAPMLDDLRRLATARPEANRRDPLADLIVVTGNL--------TATASQDEFDRAHDFLAALADGLDLPRD------RIVAVPGDLDVN-----------------DALCESYILQERAYRKPAVEPFWPKWEFFANFLRRLHGDEAEARFRLG-REWSVVA-----------------------FPELRVVVAGLNSTM------ARTH--EIRHAELGERQLRAVVE-ELDSGPWQDWLRLGMVHHAPTGSAEP-----------------G----VHLRDGAAVEEVLAP------RLHLLMHAGDS- Calcineurin+iREase WP_158072924.1 TVLHLPNLRIGDGEAFV--------------------------AGPGQTGAP----LRALGRDLVDDVRRMADE------AGHGPDLVVVTGDL--------TASARRPEFTQAATVLADLAEALDIPRE------HVAIVPGPRDVN-----------------HDLCRGYFASCAGDDEEPEPPFWPKWKHYRALLTAFYPDTTDCGFLVD-QQWSLFE-----------------------MPRLWVAVAGLNTTF------ATTHLTSPP-ATLGPRQERWFDA-ALAPYEQRGWLRIGIRHHAPEPPRG---------------GD-G----RPGPAAGADSTPEGG------RLNLLLHGEPE- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller RGA05417.1 TVLHVSDTQFGAHHRHG--------------------------AE---GVTEQDQTYSSLAARLLSDVKRLREE------HGVSPDLVVASGDL--------AEWARPAEFDQFYDFLTELASGLGLSRS------RVAMVPGNHDVN-----------------WKKCEAYFLNCQGDDTEPVPPYWPKWEPYAQTFTRFYDGVPGVSFARD-QPWTLFE-----------------------MPELKTVIAGLNSTM------AESHRDEDHYGYCGEAQLRAFAE-LLSAFEREGWLRIGVMHHNPVIDDE---------------HD-D----AFLRDRAAFREILAP------RLHVLLHGHTH- Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_133087420.1 TVLHLAGPDFGRG------------------------------------REP-----EALRREMRGDLIVLRDS------GAPAPDLLVVTGDL--------TASGSPRECDQALAFLTSVRSLLDLPPQ------RVAVVPGAQDVN-----------------QSACRAYFHTCEADEVAPQPPYWPKWRHYTRLFRSFYHGLD-TVFDSD-QPWTLFP-----------------------VPELNTVVAGFNSSI------AHSHRLEDQYGHVGRDQAAWFAE-ALRTYEEEGWLRIGALRHPLTPGTRPGDAD----------GG-P----GALDDSATLTELAGP------RLHLVLHGPTG- TIR+Calcineurin+iREase+GspA-ATPase+BetaPropeller WP_118947925.1 TALHLPGPRAGGR------------------------------GW---AFTA-----SDLLRDLPAD---------------TPPDLLVVAGDL--------TEQGGKAEFAQAFRLLADLAEDLALPRD------RVLVVPGAHDVN-----------------RKACKAYFDTAEADDEAPVPPFWPKWKQFSAAFDRFYDG-HSPTFTAD-EPWTLFE-----------------------IPDLSTVVAGFNSTT------ADTH--ERATTSLGRDQVARFRT-WLDGFREPDRLRLGVVHGES------------------------------------------------------------- Trypsin+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller KQM03099.1 SVLHLSDLRFGGSDETD--------------------------GD-----------AQSTLTPMLDDLRGLGAKRSGVDGHAAIADLMIVTGDL--------TRTASEDEFDRAHDFLAGLADGLGLARE------RIVVVPGDLDVN-----------------AALCKAYVALEDAYHRTAVPPHWPKWAFFAGFLRRLHGAEAEARFQQG-HEWSVVA-----------------------FPELKVVVAGLNSTM------AQTH--EVRTGEVGERQLSAVVK-ELDQGGWEGWLRIGAVHHGPASVAG---------------TDAG----ALLHDGGELDRLLAP------RLHLLLHGGHG- TIR+Calcineurin+iREase+NACHT+BetaPropeller MBO0806477.1 AVLHVPGPRFGRGLPEA--------------------------GV---PATA-----EELQARIWADVNRLADA------GAPRPDLLVVSGDL--------TESGSLREFDEAATFLTGLRALLGLEPD------RCVVVPGSHDIT-----------------RRKCEAYFADCEADDVAPRAPYWPKWRHFSRVFDEFYRDIDGVAFDAS-RPWTLFE-----------------------FPALRVVVAGLNSTM------AESHRPEDRYGWIGEAQATWFAE-RLRPRAADGWLRLAVVAHDP----------------------------ATLRDPPATAGLLGN------RLNLLLHGVSS- Calcineurin+iREase+NACHT WP_157389801.1 SILHVSGPRFGRGLPAT--------------------------DI---PTDP-----EGLQSHIWGAVTELVDR------QAPPPELIVVSGDL--------TESAHPTEIRKATSFLTGLRVLLKLEPD------RLVIVPGNHDIS-----------------KLACAAHFLECEANDRLPRAPYFAKLRLFEQMFNTLYRGLDHLLFDVG-QPWTLFP-----------------------IPELRLVVAGLNSTM------AATHRTEDDYGWVGTEQKDWFAE-QLRGYEARGWFRLGVLRHDPAPGPG--TSP----------YD-P----GVLRDAERTFRRLGP------RLNLLLRGPGR- TIR+Calcineurin+iREase+NACHT+BetaPropeller WP_084131133.1 TVLHLPGPRFGRT-------------------------------------DA-----AGLRDRIWGRLAAIERA------GGPAPDLVVIAGDL--------TESGTRRQFDAALDFVSDLRAMLSLETR------RILLVPGRHDVS-----------------HAASEAYFATCRADDNEPRRPYWPKWRHYSRMVAEFYQEVDGALFDPA-QPWHLLP-----------------------VPDLAVVLAGINTTI------AQSHRDEDDHGLVGAEQAASLER-HLALFEDDNWLRIGVAHHALAAPSV---------------SR-T----DTIRDTQLLREKLGP------RLNLLITGRGD- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_165001649.1 TVLHLSGMRLPAPPTDG--------------------------------RTP-----AELVTWLSDDLRRLAGTG--TGTKELRPDLVIITGDI--------TETGAKREFEQAYDVLAGLADGLRLNHN------RFAVIPGSHDVN-----------------EKLCEAYFLQQEGMDEEPVAPYWPKWTFFNGLLRRFYGPDADVGFQVG-EEWSLFA-----------------------MPDLKVVVAGLNSTM------AQSHLV--RHGWLGTGQLDSVAD-ALLEPAWEGWLRIGAVHHDPVAAAA---------------PH-N----SELRDTEELDRALAP------RLNLLLHGRGG- WP_012853478.1 TVLHVSDTQFGKEHRFG--------------------------EE---GLTPGDRRHSSLAARILKDVRHLEDE------HGLRPDLVVASGDL--------AEWGLPKEFKQVQEFLEELTDGLGLSRD------RVVMVPGNHDVS-----------------RRKCRRYFEECEDNDTEPIPPYWPKWEPFSAMFADFYADVPGVRFLSD-QPWTLYE-----------------------MPELRTVVAALNSTM------AESHREEDHYGYCGEEQLQWFAD-RLRRFKEEGWLRIGVMHHNPEISDE---------------TD-E----AFLRDRDRFTELLAP------SLNLLLHGHTH- Calcineurin+iREase+NACHT+Pentapeptide+BetaPropeller WP_121225260.1 TIVQPAGPRFGGD------------------------------VP---PATG----------RLVEDL------------ADVHPDLLVVAGDL--------TEHGLRSEFEQAFAWLGEVAEAVELPRD------RVVVVPGAHDVN-----------------RKACLAYFLRMEAEEREPLPPYWAKWEQYAEAFQRFYRDVP-VAFTAD-EPWSLFE-----------------------VPDLAVAVAGFNSTM------ADSHLGEVE-PEFGDEQLTRLSR-RLAEFGDRGWFRIGVTNRGRSVRGR------------------PHVVVAGLRTLNSYDVLRIDPTGFDRRTRLLVDGHWT- Trypsin+Calcineurin+iREase+NACHT+BetaPropeller MBI3687741.1 TVLHLGGPRFGRGLIEP--------------------------GA---PVTP-----GELQERLVGELTLLVND------GAPQPDLVVVPGDL--------TEAGSPREFADALSFLTGLRVLLGLEPN------RLVVVPGSHDVT-----------------RAASVAYFATCEADDIDPQPPYWPKWRHYARLFEELYDGLDGPVFDSA-QPWTLFA-----------------------IPDLQVVVAGLNSTM------AFSHRQDDRYGWVGEAQAAWFAQ-RLRPYHQAGWLRLGVMAHGSGAAMPYGEAATV------QIRS-G----GVLRDHASFGRLVGP------MLNLLVSGAPA- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_137251608.1 SVLHVAGPRFGRTMGA---------------------------EP---PLSP-----SGLQSHIFAELTRLTDA------GVPRPELMVVAGDL--------TAAGSRKQMTDALTFLTGLRALAGLEPQ------RVVLVPGARDVN-----------------LAACEAYFNDCKADDERPEPPYWPKWRHFASLFREFYQGVDSVMFDSA-QPWTLFA-----------------------IPELKVVVAGLNSTM------AISHRTEHRFGLVGESQAAWFAE-RVRAFEREGWLRLGVVHHSLTPGL-------------------P----DSLTDAAVVEGLLGG------KLHTILQGGGR- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_155368178.1 TILHLSDLMLGPGKVFG--------------------------AE---HSSP--------WRQVLDDLCGCVDTQLNNGDFGPKIDLVLVSGGL--------TIGGMPAEFDVAREFLEGLTRHLGIGFD------RVAVVPGNHEVN-----------------LAACRAYFADCDADEMEPVEPYWPKWRHFTKLFQSWPEQGAKVRIEAE-QPWSLFE-----------------------IAPLKVVVAGLNSTI------KDSHRQTERFGWVGEQQAEWFAD-QMERYRHRGWLRVGMVHHHPLGRAG---------------SP-E----EDLRDAANLDERLGR------GLNLLVHGHGD- HTH+Calcineurin+iREase+NACHT+BetaPropeller TMC06665.1 TILHVPGPRFGRT------------------------------DG---AVGP-----AGLQERIWADVTALADR------GAPAPDLVVVSGDL--------TESARLGEVDQALRFLVGLRDVIGVEPR------RLIVVPGPHDVS-----------------RAACRAYFFQCEAEDRQPQPPFYPKFQHYAKLFTTLYHGLDGPVFDSG-QPWTLFD-----------------------VPELRVVVAGLNSSM------GIDDRPEADHGLVTEAQATWFAN-RLRHYEDAGWLRIGVVRHGPLTGGG--LAD----------GR-A----DVLRDAGTLDRLLGR------RLNLLVHGPGA- TIR+Calcineurin+iREase+NACHT+BetaPropeller WP_073885747.1 NVVHLAGTRFGGD------------------------------GD-----------RDHLLTALHEDLDHLAAE------EGLRADLLVLAGDL--------TERGLRTEFDHAVTFLDALAEAVELSRD------RVVVVPGTHDVN-----------------LVACRAYFLDMEAEQRDPVKPYWRKWKQYGDAFDRYYRDV-GATFTPD-EFWTFFT-----------------------VPDLRVAVAGLNSTV------ADSHLDSGT-PEVDAEQLRRFAA-HLERYRAKGWLRLGVVNRPTSGVER-----------------------ELVR---------------PQLVNHL------- Trypsin+Calcineurin+iREase+NACHT+BetaPropeller WP_203383196.1 ALLHLSDLRLGGR------------------------------------EEA-----SGADRRLPTEIGKQVEL------SGISPDLIVVSGDL--------TVAGDKWALGSAAIWLRTLARSLHVSPR------NIVVVPGERDVS-----------------ARLRE--LVHEQSRFLEPTAGA-DLWRPFAVAVDQLDPQAGRLGFTAE-RPWTVFT-----------------------FPDLRVVVAGFNSTI------RLSRHDGDERGLLTRPQIEDLAD-RLRPYRDEGWLRLGVVHHNPARADQ---------------AE------QSLEDAHELGQVFDD-----ELISVILHGHAT- Calcineurin+iREase+GspA-ATPase+BetaPropeller MBV9163235.1 ALLHVPGPRFGRGIAE--------------------------------PLTA-----RDLQSRIWANVTQLTDA------GAPAPDLILVTGDL--------MESGRPRERDDALTFLTGLRVLLGLEPD------RLLIVPGNHDVS-----------------RAACHSYFLQCEARDIQPQRPYFPKLEHYTQLFDELYQGLDGPLFDTA-QPWTLFA-----------------------VPGLRVAIAGLNSTM------SVTHRPEDDYGWIGEEQAAWFAK-RLRPFEDSAWLRVGIIRHDPDPGGG--SAA----------SD-P----ALLRDTGTLDRLLGS------RLNVLLHGPGP- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_152772778.1 TVLHLAGPAFGRG------------------------------------QDP-----AGLQAAIWGDLVELTDA------GAPAPDLLVVTGDL--------TASGSPREFEQALAFLTGLRALLGLEPH------RVALVPGGRDVN-----------------QAACRAYFSTCEADEMPPRPPYWPKWRHFARLFQELYQGLD-AVFDSD-QPWTLFP-----------------------VPELHTVVAGLNSSM------AHSHRLDDQYGMVGPEQAAWFAQ-ALRPYEDEGWLRIGVLRHPPGAVPRIGAAPRPGPARAGAPDD-A----GPLRDTDVLARLTAP------RLHLLLHGPTG- TIR+Calcineurin+iREase+NACHT+Pentapeptide+BetaPropeller NUT99099.1 TVLHLSDLKIGPGRVFGR-------------------------RA---QADP-----DALTAALHRDLDALHEE------TGLRPDLVVVSGDV--------TAAAKPADVDAAAAVLTGLLGHLGLAPE------RLVVVPGGHDVN-----------------RQLVHSVFLSCEADEIEPTPPYWQKWTHFARLGAAV--GGRAARFEPEFHPRVFAE-----------------------FPDLRVVVCGLNSTI------ADSHREQDHYGLVGDDQAAAFAR-ELQPYEKQGWFRLGVVHHNPAGTAP---------------GD-H----ENLRDAATVDRLLGK------TLNVLLHGRPG- HTH+Calcineurin+iREase ADG88198.1 TLLHIAGPRFGRGLPKG--------------------------DE---PLEA-----GELQASIWGDLTRLADA------GAPRPDLLIVTGDL--------TESGVPREYEQALGFLTGLRVLLGLEAN------RLIIVPGPRDVN-----------------KKACEAYFTGCEADDVRPTPPYWPKWKHFASLFKELYQGLDGTIFDTA-QPWTLFE-----------------------LPELRTVVAGLNSTI------AMSHRAEDDYGLVGKAQAAWFAE-RLRPHGDR--LRIGVIAHPP----------------------------DRLRDSESLQRLLGS------RLDLLVHGHDPR Calcineurin+iREase+nSTAND4+BetaPropeller+BetaPropeller+BetaPropeller WP_067721052.1 SILHVAGPRFGRAGTLD--------------------------AA---AHDP-----ETLQSQIRGAVGELADR------QVPAPDLLVVSGDL--------TESANLTEFQSAATFLRGLRVLLKLEPG------RVVVVPGNHDVS-----------------KPLCHSYMLECEANNRRPQPPYYRKLELYERMFTEVFRGMDDLVFGST-QPWTLFP-----------------------IPELRMVVAGLNSTL------AATHLADDDYGFLGDPQALWFAE-QLREFERQGWFRLGVLRHDPLPDTG--TSP----------WH-P----ELLRDTAAAFRHLAP------RLNLLLHGPGP- TIR+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller REF96993.1 TILHLAGLGLAAGHLFG--------------------------APVVGQDNP----HLELCNELAAELKSLDNT-----IDGARPDLVVVTGDL--------ARTGRPREYDLVKAFLETLAERLGLGFE------RIAIVPGSRDVN-----------------LQATKAYFAECDADEVEPRRPYWSNWSRFAALFGAWPDAGRVVRMQAE-QPWSLYE-----------------------IKDLKVVLAGLNSTV------EDGPDRTGHGGEIGIEQAQWFAE-ALRDYERQGWLRIGLVHHDPLGGRA---------------AG-D----GDLGDTATFDGLLGP------RLNLLLHGNDA- HTH+Calcineurin+iREase+NACHT+BetaPropeller+BetaPropeller WP_196197147.1 TVLHLAGPAFGRG------------------------------------QEP-----DPLRAAIWSDLVELTDG------GAPAPDLVVVTGDL--------TASGSPRECDQALDFLTKLRSRLALDPQ------RLAVVPGGHDVS-----------------QAACRAYFHSCEADEIHPRAPYWPKWRHYTRLFQELYQGLD-LVFDAD-QPWSLFP-----------------------VPDLHTVVAGFNSSM------AYSHRSEDQFGSLGNEQITWFAQ-ALRPYQDAGWLRIGAVRHPLDRAPR---------------PR-R----EALRDSDLFLRLAAP------RLNLLLHGPDT- TIR+Calcineurin+iREase+NACHT+Pentapeptide+BetaPropeller+BetaPropeller+BetaPropeller WP_161102191.1 SVLHVPGPRFGRTLGGP--------------------------DD---PTTA-----TELQDRVWSDVTRLADQ------GVPRPELLVVTGNL--------THSGSRREFTEALSFLTSLRALLGLEAH------RVVVVPGEHDVT-----------------RAASQAYFASCEADDVEPQPPYWPKWRHFAGLFAEFYQGLDELIFDSA-QPWTLFP-----------------------VTDLKVVVAGLNSTL------ALTHRPEDRYGLVGRAQAAWFTE-RLRRFEADGWLRIGAVAHSPAA------------------GE-P----DAVRDAGDLDAVLGR------HLNLLLQDARA- TIR+Calcineurin+iREase+NACHT+BetaPropeller TMC12454.1 TLLHLSETRFAGA-------------------------------------GP-----EASLAELAADVEGLAAE------AGARPDLLVVTGDL--------AEAGRPSELAQARAFLAGLADRLGLPRE------RLVVVPGDHDVS-----------------RSASLAYFNTCEADELAPAPPYWPKWRHFSRMVEELYREVPDVTFDAV-QPWSLFE-----------------------VPELRVVVAGLNSTT------AESHRPEDHYGWIGEEQARWFAE-RLAPYREAGWLRVGAVHHNPLAGDA------------------G----DGLRDAEAADRVLGE------HLHLLLHGHDRM TIR+Calcineurin+iREase+NACHT+BetaPropeller WP_178064719.1 TVLHLSHLRFAPGQAFG--------------------------APV--PAGA----HEEVLAALCADLDLLARS-----LPGARPDLVVVSGDL--------AVTGRPREFDLVKSFLEGLAEHLGIGFG------RIAVVPGERDVN-----------------EAAARAYLAQCEADDVAPVKPYWHNWRHFATLFDAWPEDRQQARMQKE-HPWSLFE-----------------------LPDLRVVVAGLNSTIDA----EPGAGAGPRPGRIGAEQARHVAE-SLATYEERGWLRIGVVHHDPHGRSE---------------PA-H----ERLADAELLDGALGH------RLNLLLHGNGD- HTH+Calcineurin+iREase+nSTAND4+BetaPropeller+BetaPropeller+BetaPropeller TQM75309.1 TILHISDTQFGAKHRFG--------------------------NE---GLTAGDRRLSRLVSRLLEDIALLRRT------HGLEPDLIVTSGDL--------AETGSRSEFQQVRDFLAELAAGLGLGRN------RVVMVPGNHDIN-----------------WRKCEAYFLNCEADETEPVPPYWPKLEHYAAMFAEFYAGVRGVSFPKD-QPWTLFE-----------------------MPEIKTVVAGLNSTI------AESHRPEDHYGYCGDEQLYWFAD-RLSARAADGWLRIGALHHNPVILDR---------------ND-S----AFLRDHDRLAELVAP------HLNLILHGHTH- Calcineurin+iREase+NACHT+Pentapeptide+BetaPropeller+BetaPropeller