#iSirtuin sequence alignment
Consensus 90%         .........................................................hh_h_W__lh_______h___b___.......__..____hl__h__ss___..._s_c_lslhh__u__s_...........__________hpbhp_h___.___lhhlu......_____h__hh...._____hphh_________.........___..__h__.._______h___h_______.__
Consensus 80%         ...................................................._____hh_hsW__lh_psss__l_p_lp__......___..p_c_hlplhssss___..__s_c_lslhhlsub_s_..........__p______p_hshhppl_p___p_llllu.._________h_plh.._______lphhs____s___....._____s_..__h_h..h__s__phh__h__________
Consensus 70%         .....s_____h_pRph_LWl_____.........................______hh_LPWphVhs-ssss_lhp_lp__....___bs..ppRshlplhsssPssh..__s_c_LPlalLsGb_ss..........s_psb__bbRphshLppl_p__sp_llllu..s_s_____pl_plh.._pshbs_lpllss_sss___....._____ss.__shpl..hp_s__phhp_l_p_______p
Consensus 60%         .._hssslh__l_sRchhLWl____p....................._____p_h_phlsLPWphVahEsssssllpsLcss..._pssbs..ccRuhlpllsssPssh.._hspRsLPValLsGppss..........s_sshhpppR+hsMLppLpc__s+pLlVlG..sss_p__spls-la..psuhps_lsllss_sssssb..h____ps_ss.__slsl..hpsssscFhpslhsphs_s_s-
Consensus 50%         ..plssslhppLpsRchhLWlpp__c.....................p___ps_lsplluLPWchVahEuusssLlchLcsh..._psshs..R+RGhlcllcs-Push..sLPsRhLPVaLLsGRsss..........spsuhhsppRRhsMLccLpcu_s+pLlVlG..ssssshhscLs-LW..pcuaRspLslVossssussp..h__ahsssus.sphlsl..hpsshs-FhcsLhschssshs-
separator             ==========================================================================================================================================================================================================================================================
Annotaion                             B1                                               B2                              B3                   B4                                           B5                               B6                        B7
ss_from:MBZ5534083.1_A-----HHHHHHHHCC-EEEEE-HHHHE-CC-----CCC-HHHHHHHE-CC--HHHHHHHCE--C-EEE--CC-HHHHHHHHH----HHC-C--CC--EEEE-CCCCCC-----CCC-EEEEECC-E--C-CC-CCCECCCC-HHHHHHHHHHHHHCCCC-CCEEEEEEC----CCCCCHHHHHHH--HH-CC--EEEEEEEC---CC-----------C-CEEEEE--EEC-HHHHHHHHHHCC--ECCC
MBZ5534083.1          SPSLPPEVVRAFIDRKAILWVCQKYDLNSGEQPHDYDLPTPQTIARYRKFPDKIDNQIAQLYWEAIWLEGAASPLLQTFRAS----SAQGK--ENRPVVLLASASDTQAR-VPVEEFLPIRVLPGVIDA-NAPLDAQYGVTKGRVRERTAWDLASQLDQYRGRTLVVLG--AVGESDLARLFEVL--EDTPALDLDVLIVGPGPTAT-----GNQPMLA-GVRVVW--LNGETAELLKAISDAGAPSSRE
WP_220239917.1        PESLPPSVVMRLRDRHALLWTCQVRDLVAGAEPHDYSVDETAAALRYRLQPDPLDLRVASLYWEAAWLEGAASPLLPALRAA---AQAVKP--EARQIVVLAADDDASAD-LSSREFLPVCVLPGVLDP-EAPAAIRYGAVRARVRKRIAWSLAKRLGQYPGRVLVVLG--ARTDDDLDLLSEVL--EDCPIVDLEVLLVWPPDAPP-----PGLHTSA-SIVLHV--WRGTQDDLFTAMDEAGAPQTTA
MCC6262023.1          DKSIPNDIVKQLQDRRALLWVCQRHDLIGGEEPHDYDLPTSAAMLKYRSGPDDTDRRLASFYWESVWIEGAASPLLESIRTV---ANAQPAA-QKRQVVVLAGAADAAAR-VPSEEFLPVCVLPGLIDE-TASPDSRYGAMRARARNRVAFDLASRIREYRGRTLVVVG--ARTTDDLDRIYEVL--EDSPITDLRLLVIWPQGADQ-----PDRPSNP-TIAFSV--WAGDEAEFATALEAASAPVAGD
MBN1461339.1          SDSLSPPVARLLRERRGLLWICQPHDLKPGESPHGFELPAVEAGLRYREAPEELDRDLAAFFWEAVWLEGAASPVLDALREV---ADQQPS-DSRRSIVVLASEADAGAH-VSSQRFLPVYIMPGLIRE-DCAPDARYGVSRGRVRERIAWDLRSQVEHFPRRALVVVG--AQSETDLEPLYEVL--EDRPVIDAHVVVVWPAALPT-----PRAPDNA-ALSFHV--FQGTTAQLTKALAACETPSAAE
KQY38743.1            PDSLPTSITMRVRDRRALLWACQAHDLRPGEEPHDYSASAADATIRYRLEPDHLDLDISAYYWEAVWLEGAASPLLPALRAA---TQMTEP--EVRQIVLLAADEDASVQ-LSSREFLPVYVLPGVLDP-DAPPSSRYGAVRERVRERTAWTLAERLQQYRERALIVLG--ARGIEDLVRLSEVL--EDCPIVDLEILLVWPPEAQE-----PDLPTSS-SVVVHV--WRGTEADFFAAMAEAGAPRVTD
WP_195787617.1        --ELDDALLRCLRSRRVALWIEGTVQ-------------------------SGILNEAAGLPWVKIWSSVSRASLSSALAHA-------KN--RKPLFFDRPDDAPQAW---NESEYIVVYDVQSSTTS----------DRLELVRRQAWNEGLKQLIQGWDGIILILT---------ERMASLQ-----LGRDIELISALAPASIIVLQHGLLSGASA-DGLTNLVTWQGPLLDFVREALSVCSEQEKV
WP_216957335.1        ----------------------------------------------------STIIRVLRLPWLAIWSEVENDRLSKILASL-----DDIP----AVVVHALSDVPPTT----RGRGITYIFDTSISTG---------AAHSAILRKRRHAEELENKVEGYEGVVIAVG----SGERLQRWHEIL---SALAPEAKLIVAPPTGSGP---------GPS-LEGATP--WDDSANQLLDAISSYYVELGKE
WP_139314106.1        --DIADSVHEWRRSSQAALWLTEDCD-------------------------ANSAGDLVEIGWARVWSAVSPQALEQSNSER----NSRLQ------FLHSRNEVPMEG----AHRGIQFIYNTSREVV----------GAETADLRRRRAEEMENIVEGWRGAIVVIG------KLSDQLAELF---RSLAPTAQIFVIDSDDAES---------------RASL------VQDFLKILQSLENLVADE
PWC95993.1            -----------------------------------------------------------------VWSGLPANVVAPLLDEQ-------------RRLYQIIDNKHDLPS-VGANVNLTVILDISVSNT---------ISRPKNFLKSRHAAELENEIEGFSGLLVCAG----------TANQKW---------IEIVQALAPSATI-LLADWPSDIPKQDSEPLL--WPSGLLDFFDKVEAHLQDRSSA
VFK55423.1            ----------------------------------------------------------VGLPWVNIWDASPEFDVSNLWESV------DNS--RRPFKVDRPEQDHNNF---PVSEFVRIYDVKQRETD--------------GLKQKRSIDRLKDRIEESNGLLCFVG------RAQKNWDDIH-LAQELADGMDIVVLDAEEAAG------LSDDCP-KILLW---WDKGAESFANACKAMIDLGDAP
WP_007413374.1        --QFPDTVMHSLANRDVALWLGDGLD--------------------LSSTNLENLREFISLPWKMVLCESNEPRLIQTIQSI-DAAGTPVD--RRRGFVHVVASDPEGT--QLPPRALPVFLLSGRRDA---QVPEEAASLGRLATTRRRLNMINQLVAARPRTVILVS--AGREQPLADFFALW-KEESFRSLICLVSSAEADAKR--MDEWLGESGS-APAVDH--CESPLSLLVPSLAGRLKAVFTE
MAX25603.1            ----------------------------------------------------------LDLPWQAVYVNSSELPIVEARAQL------RGE--ERGARLRIVIDDPSDY--IFGPESVPVFCLQGLNSE------SSSTNLPKLIHDKRYLNMLSKMPLH--QFIFFIG--AAGKNDLGIVHDVA----QIAQTIGNVIITTDQYNR--IDLNFSEQLP---SLYL--WESSENQFVETLMQLNQSSDYS
MCB5288452.1          --KISDDVLFELMNREAALWVCENTL--------------------IDEEQITLLAQLMVLPWKVVLCESSNAKLIEKIEKY-GALEDELS--LQRGFVHIIASNPNVR--QLPERALPVYLLNGRSDS---QELSESPNLSGTSAMRRRLNMLERLESSLPKQVVVVG--TKVDEVAKQLAELW--STEFRAFLNFVVPETIVSKS--ITDHFESVAD-ISSVTI--VYSELSEFASYALNRCNEIIPD
EKA39993.1            --NISDSLVSSIETRDVALWIRELGD---------------------IE-STDPIIAFASLPWRAIFIENYNANLVSALENA-SDFDSIET--RRRGFVQIIDNDPTAS--QLPHRCLPVYLLNGKNEA----------NATDFKSRLRHLSMLNVLQESQVRSVVVIG--DGEDIIPPSLTELW--KAGFQSYLTVCSQRQDATDL--LTKWVESHSR-AKVVNL--LSLDITSAAIETVSKYRQTYPE
WP_164572113.1        ---PPSKRNDILIQRYASLWILPDAK-------------------------LSDVEPLINFPWINIWNTNPSIDIEQLLSLS------STG--RQAVIVESADADVSDF---PSDRFVRVYSTTSQKAI-----------RSKTLAHFHSMQLKNRVSDA-VGLLIFVGKLDRAGDDLSFIQEVA-------PQLHLITFRHDTPIA------PDSPGQ-SDIYCF----RDSVEFLDTFRSRIDDAPPQ
NLY00504.1            --KLPDSYMRHIASRDCALWVGEGFD---------------------QPDEIQAVVELIQLPWRMVLCESSEAGFVQSLEAVAQRSEAQFT--HARGFLHLVASNPEGV--SLPPRALPVFLLNGRADA---QDPSESSKRTGMAHKTRRLNMLNTLVRAKPTSLVVVA--NDDPRLLEQLVELW--QDGFRCLLSVASKSAEDGKR--IDAWLTQPES-PSAIDF--CPVAVTDFADDLIARTRLEIPE
WP_069909107.1        --GVPVPLFSQLDTRDAALWVMNADL---------------------EPAQRGALADLMRLPWSVVLCEIVNSELNETLEST-ELIESVLV--RRRGLVHLIDTNPSDY--PLPPRSLPVFLLNGRPTT----------KLSAMAALTRRLTMLEELRRHPVKHLVIIG--SPDQRALEELSGMW--EDGFRPSISVVSDNP-SESD--IPSWIDRTGA--PAVGV--LELSLVEFSQQLADRFVAD-RD
WP_070289237.1        -NSFSDSLIVGLADREATLWVCGTIN---------------------DPAKITALVAMLRLPWKQVYVEDANPRLAEELANQ---DSDALV--RRRGFIHVIDSDPSRF--SLPARALPVFLLAGRNGE-----------GSGFQRQLRQLTMLDELRRSNVRQLVVVG--DADKPFPTSLDDIW--DTGFRTRLTVVDASEDASRR--LAAWLDTHGQ-GPTASV--ISLDAQDFAERLVVAFNANYEE
ACI97505.1            ---------------------------------------------------------VLGLPWAFVFSESSDQALITALEAT-ESVESPLV--RRRGIIHIVDTNPSDV--PLPPRSLPVFLLNGRGGT----------RNSGLAALTRRLTMLEELQRRSIKHLVVLG--GPTFALPQELTGLW--AEGFRSFTTVVSDASDATDK--AAAWRAETGA--RTISL--VTTAAGAFVDDLVRRYMEG-RD
WP_146111487.1        ------------DTREAALWIHSLPH---------------------TLEESDEINKFLGLPWRLVLAENISNSIIKKLNAA-ESVNDPST--RKRGFIQIISTNPTNM--ELPHKCLPIYLLNGLDNS----------VKNSFEDRLRKMMMLEKLRSSGVRELLYIS--NSADDNFNELKELW--HSGLRCSLTFSSDFKESPQI--FEKLIQDLDD-IKAANF--LLPSTREVMQKILNSYNEVYPS
WP_124314309.1        --AVPNSLITSIENRDVSLWVRDIDN---------------------NKFSAETLAKFIGLPWRSVFMESYCPEVIKLLESS-LSFEASET--RKRGFIQVVDSDPSAI--TLPHRCLPLYLLSGRSSL----------QTNDFKSKLRRMSMLNVLQESQVRNVLVIG--EGVDAVPAALGELW--DSGFKSYLTVCTTVPGAINL--LEQWVDKHGD-THTANF--LHRSIDELSVEVIGRYHETYPD
MBA5872715.1          -----PAWAVSLQTRAAVLWIGPDWK----------------RFLGPEGAHTEHIQSLISHPWAAVFVDASDLAVADLRELT-------IE--SLELVIRLFDVDPTVE--QLPPNRLPVYFVRGPNRT------TTAGSQVDPKGMLNRLKMLARMPAG--TDLFVIG--ISSAAELAGIAEARSIAQSLRRIIVVDTLINSLEAI---------DHD-SQSIVH--WLVGAPEFFGLLTEAENLSSEK
MBI5847908.1          --RISDNLLSKLESRDVALWIRSLPK---------------------DFRSKEALVAFLGLPWRMVISEVYSPELIEALEEG-EISGKPLI--RKRGFIRIIDSDPSRI--PLPQRCLPIYLLNGRQAAP---------ASSGFADKLRQMTMLEELRRSTVRDILVIS--ADEKPIPVELQDLW--SAGFRSYLTFVTNVPDAAVM--LQEWLGESDS-YLAINL--VNMPVIPVVEDILSRYGTTYPE
EHH2531197.1          --TLSDSTITDIMSRDAVLWIGPGFE--------------------KSGMTNELMAKFISLPWKFIFIESTDAKFLESILSV-LTDENNLI--ALRGHIHVVSSDPRDQ--SFSPRSLPIFLLNGRSNV---ADGPESANLKGMSAVRRRLNMLSYLERFSPKRLCVLA--FNDSDFLSDVAQCW--EDGYRSLLSVISTQPSIVKD-FLSKWIETESF-QLAVEL--TTSPVIDVFRELNEKVVSLLPD
MBZ0115227.1          --AVRDNLLSSLESRDVALWIRQLPR---------------------GELVATSLVPFLGLPWRLVLSEVYDSTTFQTLEAA-ASFRDPMT--RKRGFVQVIDTDPSRI--ELPQRCLPIYLLSGRRSGE---------SSHDFESQLRRMTMLESLRRSGAREILVFS--DDAGPVPPELASLW--SSGFRASLTFVSTSPEAEGE--LQDWLSGAPD-VAAATL--VKAPLSAVVVDILTRYSATYPE
HBK05877.1            -DELPGGLLSALSGREVTLWLHRLPT----------------------ELDSGELTNFIGLPWRDVMLGESTKELLDTLSSN---ANADLV--RRRGYLQLIQTDPSLL-APLPPRSLPVYLLDAQRPS-----------ESEFDRTLRRMAMLGALRRSGVRHLLIVS--DEDSALPAEFASLF--DAAFQPFVTFVSVTAAGLAT--ALAWTEGKSA-GRPVQL--VRLAPVEFIRALVARYAHIYPA
MBY0330972.1          ---------------------------------------------------------ILGLPWSLVLSEAGDAPLLAALEAQ-EDPDDPLV--RRRGLILLVDSNPADV--PLPRRSLPIFLLNGRNGP----------ASTGLAALTRRLTMLQELGRRSIKQLIILA--GPEAGLPPHLSDLW--AEGLRAAITVVSDAPDAEAL--LQAWCDAASA--TNVWL--IPRTAASFSEDLVQRYRSG-RD
WP_146591036.1        ----------------------------------------------------SLFNAVLHQGWSAVFCDIASPLESKVEQMR-------LR--SDDVILRFFKEHEGPE--SLPSNRLPVYWLRGMHGK------VGPDSAQDATGLMTRMSMIKRAPAG--QEVFVLG--VAGDEGLAGILQAAQLTDAFRELVLVGRPRYDPTAI---------ESV-SRRLFI--WDTDPAGFATVVEEATRPDEGQ
MBX9458200.1          -------ILSLLDQRDIALWIEKPFA---------------------DSVSTDALADLIRLPWSVVLSDAGDEHLIENLEMS-EPIDSALV--RRRGFVQIVDGDPRDV--VLPPRSMPLLLLNGRASS----------TSRGMAAAARRINMLQELTRRSVKQLVILC--GPSPTVPDDFDALW--SDGFRTSLTVVSDDPDAQTN--WSGWLQTAGA--QAIGL--HRDHPEQFCRRLYSEFVSA-RG
WP_145440322.1        --QIGDSLFTDLHSRDVALWLGEGVG--------------------DSNSHSDSLAEVVSLPWKVVLCETVCSSFATKLETL--KDDPSLV--NYRGYIDIIAANPEEI--PLSTRTLPVLFLNGRDDS---DDPLEKPNLSKQKQLLRRLNMLKRLQDEKPRHLVVVS--SGDGTCIEEIVSLW--DEGFRAQLTIVTTSIDEINK--LKSDLLAWHQ-IEVVTV--VEQKPIDFSLDLVKRSQSHFYP
WP_080850155.1        SAAIPAPILTQLDSRDVALWLSGEED---------------------ALAPQAAIA-MSRLPWNIVVSDRSDEPYVRGLERP-EPIDDPMV--RRRGLVHVVDSDPADV--LLPPRHLAVLLLNGRGTQ----------RRTGLAALTRRLTMLQELRKRPVRQLVVVV--AGKFEVPPELGELW--DDGFRTVVTFVTDDPGAGEE--IGIWCADRNP--SAIQL--LRSVPAKFADALERDYLRG-RD